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The age estimate of this event clearly reaches back into the mid-Pleistocene, based on moderate substitution rates of 1%/MY for the CR, or moderately faster rates for the ND-1.
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The second one is based on random cell substitution with in silico-generated cell replicates.
Treatment regimes based on opiate substitution (eg, with methadone and buprenorphine) have strong scientific evidence of effectiveness.
The data embedding operation is performed based on pattern substitution.
The implementation of SPC is based on the substitution of key path components using regular expressions.
We present a new method based on phylogenetic substitution mapping.
Results based on simple substitution methods were substantially different from those based on the MI method.
We selected fast evolving genes in the syntenic segments based on nucleotide substitution rates.
LG4X is a mixture model based on four substitution matrices [ 55].
Regular scoring schemes are based on a substitution matrix, used to reward identities and penalize mismatches.
In this work, two different methods were used: one based on a phylogeny-based substitution rate and the other based on a fixed substitution rate.
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