Sentence examples for based on modelling studies from inspiring English sources
Based on modelling studies and X-ray analysis, a model of the binding mode of these novel compounds in the MMP active site was obtained.
This review discusses the approaches proposed by several research groups working on the synthesis of HDAC inhibitors, based on modelling studies and the way these findings were used to obtain new HDAC inhibitors with possible isoform selectivity.
4 These figures are, however, largely based on modelling studies using cross sectional data, with several key assumptions.
Our assessment of substitution of the pyrazole ring focused on the 4-position, since no further space is available for position 5 based on modelling studies of 1a with the BRAF structure reported in the co-crystal structure with SB590885 (Fig. 2).
Moreover, soil ecology journals publish low percentages of articles based on modelling and evolutionary approaches and, conversely, journals specialized in evolutionary and modelling approaches publish low percentages of soil ecology-related articles.
This estimate, however, was based on modelling breast cancer deaths regardless of period of diagnosis.
Studies on the substrate scope of this strategy are presented and a catalytic mechanism is proposed based on molecular modelling studies supported by mutagenesis of amino acid residues in the active site.
Contrary to expectations based on atmospheric modelling studies, tephras appear to be at least as abundant in Ireland and northern Scotland as in Scandinavia.
Based on the modelling studies the lycopodane-type alkaloids seem to fit well into the active site gorge of the enzyme but the position of their functional groups is not compatible with establishing strong hydrogen bonding interactions with the amino acid residues that line the binding site.
The timing and number of educational sessions is based on previous modelling studies with a group of 8 practices.
A recent meta-analysis, largely based on US modelling studies, suggested that for every 1% increase in price, energy intake would reduce by 0.02%.
