The common way to uncover miRNA targets is to directly test miRNA expression levels on different mRNA profiling [ 83] or to use different phenotypes to test expression levels [ 84] based on microarray [ 85].
(XLSX 25 kb) Additional file 5: Kruskal-Wallis test statistic for combined expression profiles of target genes based on microarray and qPCR data.
We found a significant difference in biogeography based on microarray analyses when comparing Sørensen similarity values for presence/absence of function and phylogeny (Student's t-test; p = 0.005).
Each of the 3 tested methods performed surprisingly accurately when amplifying from low inputs of total RNA based on microarray analysis validated with QPCR of 37 genes.
The proposed framework of system has been tested on two well-known tumor microarray datasets with encouraging results and shown great potential for the developments of generic platform for tumor clinical diagnosis based on microarray data.
The problem of uncovering transcriptional regulation by transcription factors (TFs) based on microarray data is considered.
Many studies have selected candidate miRNAs in EVs based on microarray results and validated them by qRT-PCR.
Bayesian networks can be used to expand a pathway network based on microarray gene expression data.
Four promoters were tested, ranging from high to low expression, including those for mxaF, lac [ 22], and two chosen based on microarray data [ 23– 25].
This computational analysis is solely based on microarray data.
