Sentence examples for based on miRNA profiling from inspiring English sources
Thus, it was illustrated that it is possible to distinguish different cell types or different cellular conditions (i.e., treatment) based on miRNA profiling.
Interestingly, Zhang et. al. [14] demonstrated CLL cells are more like memory B cells based on miRNA profiling, our miRNA profiling data showed CLL cells are behaving like activated B cells at an earlier time point.
Based on miRNA profiling data, breast cancers without vascular invasion show high miR-205 expression compared to breast cancers with vascular invasion (21).
The goal of identifing a method to predict levels of mRNAs based on miRNA profiling, regardless of the underlying regulatory mechanism, was strengthened by correlation against predicted mRNA targets across the entire transcriptome.
Using this model we correctly assigned stage I II colon cancer patients based on miRNA profiles of stage IV patients.
These findings set the stage for studying a sequential prognostic and predictive approach, whereby patients are stratified early based on miRNA profiles at the time of diagnosis, and prognosis is then refined by subsequent pathologic assessment of chemoresponse, potentially with additional contribution from dynamic patterns of miRNA expression in resistant tumors.
To do this, we developed a microRNA (miRNA -based systemiRNA -basedtion of gene expresystembased on miRNA expression proforing of 293-Cregulation4+ cells.
After assembling all reserved miRNA-miRNA pairs, miRNAs interaction network based on miRNA expression profiling data is constructed.
Based on miRNA expression profiling of human breast cancer studies, we found that miR-92 is upregulated in malignant breast.
In a clinical context, the challenge will be to predict which drugs may show unwanted efficacy and toxicity effects based on miRNA expression profiling alone.
Unsupervised hierarchical clustering based on miRNA expression profiles showed no clear separation between the groups of carcinomas with different BRCA1/2 status.
