Sentence examples for based on methylation profiling from inspiring English sources

These do not demonstrate a consistent pattern, suggesting around 3-4 sub-types based on mRNA profiling but a larger number of sub-types based on methylation profiling.

Nevertheless, while both methods had similar NPV, the empirical approach showed a better representation and PPV suggesting is the better predictor for tumor relatedness based on methylation profiling.

A smoking score based on methylation profile was constructed.

Unsupervised hierarchical cluster analysis based on methylation profile of this panel of genes demonstrated four main groups.

Using a subset of the 3000 most variable probes, unsupervised hierarchical cluster analysis highlighted 4 distinct subgroups based on methylation profile.

Cluster analysis based on methylation profile divided our DCIS cohort into four groups, which were phenotypically distinguished by nuclear grade, and in particular, the high-methylation cluster (cluster 4), being associated with additional aggressive phenotypic features including negative hormone receptor status, HER2 amplification, and non-luminal intrinsic subtype.

Comparisons between EcoRI/MspI and EcoRI/HpaII profiles for each sample allowed us to identify non-methylated, methylated and hemimethylated loci based on methylation sensitivities of both isoschizomers [32].

Two additional filters are based on methylation rates.

Such large overlap is in marked contrast with the single differentially methylated gene from the 46 gene list that was reported in the same study, based on DNA methylation profiling obtained with the Illumina 27K BeadChip Methylation Array (5); however, this discrepancy can be easily accounted for by the larger genomic coverage of the 450K Methylation Array used in our study.

Classification based on promoter methylation profiling may well be a more promising approach than expression profiling since these DNA-based techniques are not subject to the problems of tissue preservation and the potential pitfalls of tissue heterogeneity.

For this purpose, we designed three pairs of methylation-specific primers based on the methylation profiles of the TGFBI promoter reported in human tumor cell lines [ 16].