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We hypothesized that by adjusting the level of cholesterol in anionic, unsaturated liposomes we could tune the enzyme specificity based on membrane fluidity, thus obtaining liposomes with an improved therapeutic outcome and reduced side effects.
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This implies that previous suggestions that DHA has "unique" biophysical effects on membranes13,20 cannot be explained by its effects on membrane fluidity.
We employed the fluorescence recovery after photobleaching (FRAP) assay to explore the impact of LDs on membrane fluidity of lysosomal-like liposomes.
Not only cholesterol (and maybe cholesterol modifying therapies) but also micronutrients can play a role on membrane fluidity [178].
The effects of the Rvs161/167 BAR domain on membrane fluidity and lipid order are dependent on lipid composition.
Because of the influence of DHA on membrane fluidity, it has been speculated that DHA has significant impact on neural membrane function.
In conclusion, our results suggest that flavonoids supplementation in dyslipidemic patients has a beneficial effect on the cholesterol concentration in erythrocytes membrane and on membrane fluidity.
Due to the potential effects of MUFA ratio alterations on membrane fluidity, we cannot fully disregard a variation in toxicant access through the membrane.
The negative effect of low polyunsaturation on membrane fluidity may be counterbalanced by the higher percentage of MUFA and the known low cholesterol content of mitochondrial membranes (117).
We note, however, that AmphoB did little to alleviate either IFITM1's antiviral action or it's inhibitory effect on membrane fluidity and cell-to-cell fusion.
The effect of ApoB-100 on oxidized low-density lipoprotein (oxLDL -induced cytoxLDL -inducedon membrane fluidity of cytotoxicityotheliandcells using varions in vitro experimembranepproaches was investigated.
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