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Based on mechanistic data, IARC and NTP upgraded ethylene oxide (IARC 1994; NTP 2004) and 2,3,7,8-tetrachlorodibenzo 2,3,7,8-tetrachlorodibenzo7; NTP 2004) from "probable" or "reasonably anticipated" human carcinogens to "known human carcinogens".
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The phosphinic acid‐containing pseudopeptides are the most potent inhibitors of FPGS identified to date, and were designed based on mechanistic enzymology data from our laboratories and others, prior to the publication of any structural information about the targeted enzymes.
All five metals are plausibly linked with BP, based on mechanistic and experimental data (Houston 2007; Jiang and Zheng 2005; Navas-Acien et al. 2007; Valko et al. 2005).
Robust AOP data of this type could be used to screen data-poor chemicals and make inferences about their potential health effects based on mechanistic similarities to data-rich chemicals.
Models that are based on mechanistic understanding yet remain within the bounds of data-based parameter estimation can accommodate rigorous and complete error analysis.
Comparisons with models based on mechanistic views and proposed for vapor phase reaction do not offer better data fits.
Truncation of the data to be fitted is justified (indeed necessary) based on mechanistic considerations and not based on statistical classification of outliers as in some qPCR model-fitting methods [6], [8], [10].
In our case study, the read-across justification, first, will be based on mechanistic understanding in combination with toxicokinetic and toxicodynamic assessment; second, it will be strengthened by selected in vitro data.
Discussion is based on mechanistic understanding, specifically kinetics based on hydrogen assisted CO dissociation; a linear relationship between CH4 and C5+ products; possible reinsertion of olefins; hydrogenation of olefins; and surface coverage based on SSITKA data.
Thus, the lack of difference between the High- and Low-Mechanistic groups based on Mechanistic Assignment does not weaken the findings relating mechanistic knowledge and strategy use.
Table 1 shows that there were no significant differences between the number of accurate motors for the High- and Low-Mechanistic groups based on Mechanistic Assessment only.
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