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Structural diversity is not the only reason why natural products are of interest to drug developers, since they often provide highly selective and specific biological activities based on mechanisms of action.
It has been theorized that this function requires two essential integrated components, a central executive which guides selective attention based on mechanisms of associative memory, as well as the second component, working memory buffers, in which information is held online, abstracted, and translated on a mental sketchpad of work in progress.
Current rehabilitation efforts are intended to drive the nervous system to adapt to the disordered vestibular input: physiopathological basics of vestibular rehabilitation are based on mechanisms of vestibular compensation: an appropriately designed virtual reality (VR) experience could greatly increase the rate of compensation in these patients.
Yet there are no drugs based on mechanisms of disease for treating autism or the vast majority of mental disorders and diseases.
Yet despite the fact that they did not accept Lipps's explication of empathy as being based on mechanisms of inner resonance and projection, authors within the phenomenological tradition of philosophy were persuaded by Lipps's critique of the inference from analogy.
In general, crossbreeding induces genomic shuffling based on mechanisms of sexual reproduction (Snoek et al. 2015), and the resulting derivative strains may therefore acquire phenotypes different from those of the parent strains.
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(2007) proposed an objective function for fracture network modeling based on mechanism of fracturing.
First, the performance degradation model based on mechanism of contamination failure and material outgassing characteristics of SPTRs was established.
It is possible that a number of cases may have met the PMT based on mechanism of injury and co-morbidity, but were not included due to missing data.
PKC consists of nine structurally related isoforms, sub-divided into three groups based on mechanism of activation and structural similarities [9].
When selected cell lines are treated with HER2 inhibitors, we not only observe the expected molecular effects based on mechanism of action knowledge, but also novel effects of HER2 inhibition on key targets in the HER receptor pathway.
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