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Tacrolimus plasma clearance/bioavailability (CLp/ F) was estimated to be 811 l h−1 for a CYP3A5 non-expresser with 60 kg fat free mass, which may be compared with previously reported values based on measured plasma concentrations in liver transplant recipients (695 l h−1 47 and 473 l h−1 35) for 70 kg total body weight patients.
Based on measured plasma concentrations in the individuals included in this study and the population pharmacokinetic model as presented in Figure 2, Bayesian estimates of the area under the plasma concentration time curves (AUCs) of 4-hydroxycyclophosphamide and phosphoramide mustard were generated.
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Both the flow rate and ZNF experiments allowed for evaluation of stability of RR over the concentration range 1.0-5.0 1.0-5.0ch is a relevant interval based on measured plasma-concentrations in patients during HIPEC [ 6].
The level is based on measured changes in plasma acetylcholinesterase.
Kinetic constants were calculated and fitted into the model based on measured Ki values [2] and experimental PT rivaroxaban plasma concentration relationships [26].
However, based on the measured plasma levels, the generic formulation is expected to produce a similar therapeutic response as the brand name formulations.
One approach is based on measuring total τ protein or amyloid β-protein concentrations in cerebrospinal fluid (CSF) or plasma.
Pheochromocytoma diagnosis usually relies on measuring plasma or urine metanephrines.
The differential diagnosis of dementia syndromes is clinical and radiological, and there are no litmus tests based on measures in blood or plasma to specify diagnosis.
In brief, glucose was infused at a variable rate, based on plasma glucose measured every 5 min, to maintain steady-state plasma glucose levels (250 mg/dl, 139 mmol/l).
The study-specific expansion of the database included study case report forms and calculation of KDIGO (Kidney Disease: Improving Global Outcomes) stage for each patient, continuously based on every measured hourly urine output and plasma creatinine.
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