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Drug acquisition costs were based on mean doses used as described by IMS (ICD codes F20) in Spain for each treatment (Table 3).
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As pointed out during peer review, we should consider at the outset whether the data is sufficient for fitting a non-linear model based on mean dose.
for 12 months was conducted based on treatment given in the maintenance of effect phase (MPH-LA or placebo) for 6 months was based on mean daily dose given in the extension study (MPH-LA mean daily dose of ≤40 mg or >40 60 mg or >60 mg).
The primary objective of the study was to demonstrate non-inferiority of fluticasone/formoterol to fluticasone/salmeterol based on mean pre-dose forced expiratory volume in the first second (FEV1).
Background The objective of this pilot study was to evaluate the comparative efficacy of alternate-day dosing of atorvastatin compared with the standard once-daily dose based on mean low-density lipoprotein (LDL) reduction from baseline at 6 and 12 weeks of treatment.
Titration of bolus insulin (IAsp) aimed to achieve a pre-meal PG target of 4 5 mmol/L at the following meal; hence, the breakfast bolus dose was titrated based on mean pre-lunch PG values, the lunch bolus dose was titrated based on mean pre-dinner PG values, and the dinner bolus dose was titrated based on the mean bedtime PG values.
Second, based on the mean doses in industry funded trials (each of which used forced upward titration schedules) and the POTS I study, after 12 weeks of adequate treatment, full remission is unlikely with a higher SRI dose or longer treatment duration even if such increases were possible, which is typically not the case.
Secondly, the estimation of drug costs was based on the mean dose intensity from the trials, rather than the doses specified in the Summaries of Product Characteristics (Scenario B).
Based on the Mean (mean ± 3S.D).
Because of these variations, tumours smaller than 1 cm receiving peptide radiotherapy with 277.5 MBq Lu-DOTA-octreotate show regrowth in 25% of the animals, despite the TCP of 100% based on the mean radiation dose.
The mean applied total lung dose was 12.31 Gy (SD = 2.64 Gy) based on a mean ipsilateral lung dose of 19.85 Gy (SD = 4.03 Gy) and a mean contralateral lung dose of 6.52 Gy (SD = 3.34 Gy).
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com