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How accurate is combined screening, based on maternal age, using serum and nuchal translucency measurements in first trimester screening for Down and Edward syndromes?
Combined screening for chromosome abnormalities in the first trimester of pregnancy is based on maternal age, nuchal translucency (NT) and biochemical markers (PAPP-A and free β-hCG).
This DS Data Quality Indicator calculates the ratio of observed to expected DS for each registry based on maternal age profile, external standard maternal age-specific rates and fetal survival correction factors to 20 weeks GA (see Appendix).
Recent studies have reported the efficacy of first-trimester combined screening for Down syndrome based on maternal age, serum markers (human chorionic gonadotropin, pregnancy-associated plasma protein A), and ultrasound measurement of fetal nuchal translucency.
Typically, such screening procedures consist of a risk calculation based on maternal age, nucal translucency and serum biomarker measurements, after which women with a high predicted risk can opt for invasive testing such as amniocentesis or chorionic villus sampling.
Down syndrome screening began with crude risk estimates based on maternal age.
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Other time-dependent variables included child's age in years, current child care attendance (yes/no, based on maternal report of the ages at which the child attended child care with other children), number of other household members ≤ 14 years of age (0, 1, and ≥ 2), and household density (number of adults and children living in the household divided by the number of rooms).
Similarly, Jacobson et al. (1989) could explain 60% of the variance in blood levels of 107 children at 4 years of age based on maternal milk PCB and weeks of breastfeeding, whereas children's fish consumption had little relation to measured blood PCB levels.
To measure agreement between gestational age based on maternal report of expected date of delivery (EDD) 9 months after birth and gestational age at birth in routine hospital data.
The effect of maternal BMI was compared to results from weekly mother's reports of infant breastfeeding behaviors.Significant breastfeeding differences were observed based on maternal BMI and infant gestational age.
However, the data on gestational age based on maternal recall of last menstrual period may be less accurate.
More suggestions(15)
based on maternal report
based on maternal self-report
based on maternal recall
based on maternal serum
based on maternal rank
based on maternal culture
based on maternal self
based on maternal occupation
based on maternal information
based on maternal prepregnancy
based on maternal plasma
based on maternal blood
based on maternal recollection
based on maternal body
based on maternal status
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