In arteries wall, they were detected at the border zone between media and adventitia in the so called "vasculogenic zone" based on marker profile.
Our findings are also in line with a previous study, in which the genetic variation in a B. rapa core collection representing all morphotypes and geographical origins was analyzed based on molecular marker profiles [ 26, 27].
We demonstrate the versatility of NPS by successfully screening cells from established human cell lines for their specific phenotypic profiles and by distinguishing cell types in a mixed population based on surface-marker profiles.
Nevertheless, imputation using the map-dependent methods increased the power of association mapping in comparison to QTL detection based on non-imputed marker profiles.
Cells at this stage of differentiation were chosen for transduction based on their marker expression profile, which indicated a possible commitment to the germ lineage.
A panel of 183 elite durum accessions representative of the major gene pool cultivated in the Mediterranean region for which LD and population structure were previously investigated based on low-density genotyping with SSR markers (DurumPanel, [ 38]) was re-investigated in depth based on the profiles of 1,200 markers included in the consensus map.
Therefore, our study is more suitable to evaluate whether a regulatory model can successfully identify key upstream regulators (e.g. prognostic markers) purely based on expression profiles without depending on external knowledge.
However, to make a useful and robust multi-marker test based on protein profiles, test development and validation should include the use of animals that originate from different breeds, different farms, different time points post infection and from animals with different disease history.
This method can efficiently rediscover many entire biological systems, such as histidine biosynthesis genes, given a profile based on any one marker gene for the system.
