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Consequently, many care-related activities are still conducted based on manually constructed guidelines.
As a consequence, a lot of care-related activities are still being conducted based on manually constructed guidelines or flow charts.
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Furthermore, most software tools which aid in finding and/or explaining analogies are based on manually assembled databases, which require a large amount of interactive work to be constructed and maintained.
Quantitative analyses are based on manually selected ground truth data.
Research in the past was based on manually designed screens with minimal software support.
Each algorithm overestimated MBF compared to MBF based on manually defined blood pool TACs.
The morphology features were analysed visually by radiologists based on manually drawn ROIs.
These projects are characterized by the manipulation of data, information, and knowledge in various types and formats, manually constructed based on the modularity principle, where complex elements are divided into smaller parts.
To predict the RBSs on very short input sequences (having no training data), a general model of the RBS was manually constructed, based on the average RBS map and was integrated into the MGA (Fig. 1A).
We manually constructed new HMMs based on the six largest subfamilies and tested their specificity by scanning a benchmark set of all proteins that have been annotated as a member of one of the TRP subfamilies in Swiss-Prot (see Materials and Methods for details).
Due to the fact that neither Pfam [35] nor other resources offer Hidden-Markov-Models (HMM) of all the the eight PKS I domains, they were constructed based on a manually curated set of PKS I protein sequence hosted at PKSDB [27].
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