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The GENCODE consortium is composed of nine groups that are dedicated to producing high-accuracy annotations of evidence-based gene features based on manual curation, computational analyses and targeted experiments.
In addition, data sources that are not yet available to public are incorporated, such as genotyping data from Mount Sinai Biobank, a biobank established in 2007 in New York City with ethnically diverse participants [ 24], and in-house curated disease variant database VarDi [ 25] based on manual curation and literature mining.
Databases such as RegulonDB [ 13], which are based on manual curation of experimentally reported polycistronic transcripts identified in at least one experimental condition in the literature in Escherichia coli K-12, define an operon as the ensemble of all the transcription units in a given genome loci which results in the longest stretch of codirectional transcript.
CAZy proteins are further classified into families, based on manual curation and phylogenetic analysis (CAZy similarity thresholds are not public).
However, the current database model, based on manual curation, is not sustainable because the limited support is not compatible with complete and accurate coverage of published information.
Among previously reported measures, molecular weight is the least related (Figure 1), which is expected since the other cost estimates are based on manual curation of metabolic networks.
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The remaining growth rates, in the range of 10%to30%0%, are more modest but these particular sources are based on manual document curation, rather than bulk submissions.
Although WebGestalt can perform enrichment tests for the Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways [ 33], the IPA system provides a more comprehensive pathway resource based on manual collection and curation.
The PAINT curation process is a manual process based on manual annotations.
Information on these objects is acquired and stored based on the manual curation or via automated pipelines using several controlled vocabularies or ontologies.
Based on our manual curation, coding potential metric and gene-structure analysis, we conclude that NGM-vvo subset represents a set of high-confidence lncRNAs.
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based on previous curation
based on manual driving
based on manual reconstruction
based on manual interpretation
based on manual setup
based on manual labor
based on manual derivation
based on manual inspection
based on manual observation
based on manual artifact
based on manual pattern
based on manual document
based on manual screening
based on manual liquid liquid
based on manual arrival
based on manual identification
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