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In case of the CHEMDNER corpus the percentage agreement between curators for defining chemical entity mentions was of 91% (exact matches) based on manual annotations of 100 abstracts.
The PAINT curation process is a manual process based on manual annotations.
In brief, the accuracy measurement was carried out by domain experts actively involved in the development of the AGROVOC vocabulary based on manual annotations of a test sample from the AGRIS database.
Candidate ABC transporters were identified in the E. siliculosus genome based on manual annotations [ 24] or the presence of the "ABC_tran" PFAM motif, and classified according to Dean et al.[ 31].
In brief, the accuracy measurement was carried out by domain experts actively involved in the development of the AGROVOC vocabulary based on manual annotations of a test sample from the AGRIS database" It is not clear to me if the aforementioned test has been held in the context of another previous study or it covers the specific study.
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Functional categories were based on manual annotation of the custom made GrapeGen GeneChip®, based on 12X v1 grape genome assembly, described in Grimplet et al., 2012 [ 82].
Table 2 shows the number of instances in each category for the top eight cancer gene symbols, based on manual annotation.
Based on manual annotation, 3'UTR length was predicted for all sequences with stop codon and poly-A tail (in total 191 genes).
Different controlled vocabularies such as MeSH (Lowe and Barnett, 1994) and eVOC (Kelso et al., 2003) have already been utilized, and the ACGR method by Yilmaz et al. (2009) is specifically based on manual annotation of diseases with GO terms.
However, the standard methodology chosen here was automatic annotation due to the high stringency of the parameters; hence, the 84 proteins that were classified as putative mitochondrial based on manual annotation were not included in the final catalogue of mitochondrial proteins that are proposed here.
With mmp9 as a positive control, the expression of all exons is significantly expressed after M. marinum infection.The expression levels for mfap4 (4 of 13) are based on manual annotation of the unique reads in the known gene region since there are several repetitive DNA regions in common with the other 12 annotated mfap4 gene family members.
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