Sentence examples for based on mRNA profiling from inspiring English sources

Based on mRNA profiling and expression of cytokeratin 8, mouse ILC is luminal in character but does not express ER/PR during the later stages of tumor progression.

These do not demonstrate a consistent pattern, suggesting around 3-4 sub-types based on mRNA profiling but a larger number of sub-types based on methylation profiling.

This clearly demonstrates that it was not only possible to predict the compound's cytotoxicity based on mRNA profiles but also its apoptotic mode of action.

In this study, we have performed GEX profiling on 66 MBC tumors to study the disease transcriptionally and to subclassify tumors based on mRNA profiles.

As an alternative for GO annotation, we used 15 functional clusters of genes that were previously obtained based on mRNA profiles [ 21].

Different studies based on mRNA expression profile analysis led to contradictory conclusions regarding RNAi target specificity [ 19- 21].

To verify these results using an independent approach, we undertook a screen based on mRNA expression profiles, protein localization, and small hairpin RNA (shRNA) depletion.

A subgroup of specific chemokine receptors were selected for detailed study based on mRNA and protein expression profiles from a series of osteosarcoma cell lines (data not shown) as well as from literature suggesting the involvement of specific receptors in cancer, cancer progression and osteosarcoma [ 8, 12, 21, 22].

Because BayMiR estimates the activity of miRNAs based on mRNA expression data, there is no need for matching miRNA expression profiles.

To demonstrate the feasibility of OncoRep, we produced reports based on the mRNA profiles of 17 breast tumor samples of three different subtypes (TNBC, non-TNBC and HER2-positive) which have been previously analysed and described [ 17- 19].

Based on the mRNA profiles, these results show the strong bias that soybean has towards increasing the synthesis of isoflavonoid phytoalexins concomitant with the down regulation of genes required for the synthesis of anthocyanins and proanthocyanins.