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Now a new study, based on lung tissue samples preserved from the victims of what became known as the Great Smog of 1952, has provided insights into why the smog proved so deadly.
It could be hypothesized, however, that the most reliable blood-derived biomarker could be found based on lung tissue analyses with the knowledge of cell-specific localization and with an established association with the course and the phenotype of the disease.
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Most studies of gene expression in the lungs of patients who have COPD have compared tissue from subjects with and without COPD based on lung function [ 3, 5– 7].
The sample size was based on lung lesions and ADG.
Selman et al. published a gene signature, based on whole lung tissue, which distinguished IPF from hypersensitivity pneumonitis [ 11].
Similarly, in another human tissue dataset (PubmedID: 15774023), 50 lung-specific genes were identified based on one human lung tissue hybridization.
This observation could be due to a greater abundance of Lf receptors on lung tissue.
The effect of nanoparticles on lung tissue is different depending on the size, shape and material of the particles, Dhar said.
Smog, a toxic gas generated by the burning of fossil fuels, can have the same effects on lung tissue as sunburn on the skin.
AGR2 expression was analyzed on lung tissue microarrays.
Patients were diagnosed as having minimal, moderate or advanced pulmonary tuberculosis using a modified classification of the National Tuberculosis Association of the USA based on extent of lung tissue involvement [44], [45].
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