Additionally, MMP-mediated processes, such vascular invasion and chondrocyte apoptosis, might be disturbed or delayed based on lower expression levels of these genes.
A BRE motif, positioned upstream of the TATA-box, at a median distance of 33 bp from the TSS, was also clearly conserved although there was more sequence variability in the BREs upstream of sTSS presumably correlating with the sTSS being so designated based on lower expression.
† Based on lower heating values.
Based on the lower expression level of PPARα in human liver compared to mouse liver [19], the functionality of PPARα in human liver has been questioned [20].
In addition, the CD45RA+ and CD45RA− effector cells that were identified in Inf and CLInf patients showed a reduced activation state based on their lower expression of HLA-DR, contrasting with findings seen in HIV-1 infected patients [25].
However, based on the lower expression level (0.35 g/L) and the yield of purification process (assumed to be 10%), the minimum herd size of 192 transgenic sows is required in ideal condition for worldwide market.
The KLK6 gene (previously known as zyme, protease M, neurosin, PRSS6) was originally cloned based on its lower expression in metastatic breast cancer compared to primary cancer and normal tissue (Anisowicz et al, 1996).
This entity list was created by filtering based on expression (lower intensity cut-off ≤ 300) and flags to account for background, false positives and absent spots.
Although KCNB delayed rectifiers were not on the array, they also appeared to be down in HVC based on the relative lower expression of cooperative subunits (KCNF1, KCNG1*, KCNS2*), and an enrichment of an inhibitory subunit (KCNV1*) of this subfamily.
Although the proportion of affected genes in higher plants seems lower, based on published expression profile data, the actual number should be even higher than that in yeast, considering that higher plants are composed of several highly differentiated tissues and cells.
When patients were dichotomized into low and high INPP5F expression (based on the median expression level of INPP5F), lower INPP5F expression was associated with improved PFS (median PFS, 30.6 months) compared with higher INPP5F expression (median PFS, 18.5 months, Figure 1a).
