The method enables the identification of bioisosteric replacements for ligand substructures based on local binding site similarities independently from the protein sequence or overall protein folding.
The purpose of this work was to develop an effective PEGylated TNF-related apoptosis-inducing ligand (PEG-TRAIL) delivery system for antitumor therapy based on local injection to tumor sites that has a sustained effect without protein aggregation or an initial release burst.
The outputs were determined by each site based on local needs and perceived barriers to evidence-based care [ 20], and agreed to by the Australian SEA-ORCHID team.
Designers can thereby develop appropriate rainwater management strategies based on local precipitation data, specific standards, site conditions and economic considerations.
The results of local HER2 testing were reported by participating study sites based on local IHC and/or local FISH.
The study was designed to enroll approximately 50% cases with positive HER2 status and 50% with negative HER2 status as determined by study sites based on local HER2 testing.
The costs and duration of time associated with establishment and remediation of a disposal site are difficult to quantify and are likely to be site specific and based on local waste disposal and environmental regulations.
Site selection was based on local land uses and the nature of emission sources (Table 1).
Differences observed in self-reported measures and outcomes may reflect site-specific differences that are based on local healthcare system or patient-specific factors.
Much of the most hopeful talk at the Occupy movement sites is about new economic approaches based on local, cooperative, and sustainable models of market activity.
