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Tumor contouring methods based on liver activity, therefore, potentially could be particularly helpful in post-radiation re-planning situations.
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The clinical PD was based on liver and bone metastases.
With about 25% of compounds, regulatory decisions are based on liver effects - hypertrophy, enzyme induction, cancer, etc. - in rodent liver.
It is a movement based on movement, activism based on activity.
In contrast, panels based on conventional liver selenoenzyme activity biomarkers (Gpx1 plus Gpx4 activity) or blood selenoenzyme biomarkers (RBC Gpx1 plus plasma Gpx3 activity) only predicted 57% or 80%, respectively, of the variability in liver Se concentration.
There was no apparent difference in 99mTc mebrofenin overall liver exposure in the presence or absence of ritonavir based on the mean liver activity profiles.
Our territorial model keeps this basic assumption but introduces more partitions to the normal liver based on arterial liver territories, see the "Determination of arterial liver territories" section.
We propose an optimized, extended partition model, called territorial model (TM), introducing more partitions to the normal liver based on arterial liver territories [7].
CYP3A contribution to sirolimus metabolism was estimated to be 95.8%, while that of CYP2C8 was less than 10% based on the activity assays using pediatric liver microsomes and specific chemical inhibitors for each CYP isoform (Table 2).
The NOAEL for male rats, based on increased liver weight and liver anomalies, was 1.3 mg PFOA/kg BW.
Serum complement activity was determined based on hemolytic activity.
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