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Some of the most effective vaccines used for preventing viral diseases are based on live attenuated viruses.
Nucleic acid vaccines have the potential to address issues of safety and effectiveness sometimes associated with vaccines based on live attenuated viruses and recombinant viral vectors.
Most viral vaccines are based on live attenuated viruses, while many bacterial vaccines are based on acellular components of micro-organisms, including harmless toxin components.
Currently, many successful viral vaccines are predominantly based on live attenuated or inactivated viruses.
Most of the current successful vaccines are based on live attenuated or inactivated pathogens which show distinctive biological and immunological characteristics.
Several candidate vaccines have been tested in clinical studies [ 11], including those based on live attenuated CMV, protein subunits, recombinant vectors, DNA, and peptides [ 4, 10].
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The first golden age of vaccines started when Pasteur, Koch, Ramon, and Mérieux established the germ theory and developed vaccines based on live-attenuated or inactivated (killed) pathogens and on inactivated toxins (toxoids).
OPV is based on live but weakened, or attenuated, poliovirus.
Until now, upfront agreements were based on live viewership of shows.
These viewer totals were all based on live viewing and playback of the show on the same day it was recorded via DVR.
Similarly, Khanna et al. [17] propose an approach for dynamic consolidation of VMs based on live migration.
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