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There is a risk that studies based on linkage with prescription registers will be uncertain.
Based on linkage with LDS Church records, 11,291 (76.8%) of these cases were determined to be LDS Church members.
The symptomatic CRCs were also ascertained based on linkage with national cancer registry data until the end of 2009.
Each person was followed up for death, emigration, and incident cancer based on linkage with the nationwide population, death, and cancer registries using unique personal identifiers.
Follow-up was based on linkage with population cancer registries in Denmark, Italy, Netherlands, Norway, Spain, Sweden and the United Kingdom.
Follow-up for heart failure, atrial fibrillation, type 2 diabetes, peripheral vascular disease, venous thromboembolism and cancer were usually based on linkage with national hospitalization registers, other administrative registers and cancer registers.
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The selection was based on different criteria including but not limited to the statistical significance (analysis of combined AA and EA cases and controls), minor allele frequency (MAF>5%), SNP location in gene functional regions (for intragenic SNPs, further selection was based on linkage disequilibrium with associated SNPs in the initial study (Aissani et al. 2013)) and SNP assay designability.
where gSNP is the risk allele dosage of SNP, which is defined by: (P(0 risk alleles) × 0) + (P(1 risk allele) × 1) + (P(2 risk alleles) × 2); this might be a non-integer value when the SNP is imputed, that is, it is not genotyped itself but its genotype probabilities are estimated based on linkage disequilibrium with nearby genotyped SNPs.
Based on linkage disequilibrium and association with asthma, eight SNPs and one CpG site were selected for further analyses.
19 Evidence regarding adult intelligence quotient (IQ) in relation to Apgar scores comes from studies based on linkage of birth data with results of routine IQ testing at conscription.
PKHD1 is the main gene in ARPKD, but there is compelling evidence for locus heterogeneity why results that are merely based on linkage need to be handled with some care.
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