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To further elucidate the cataract phenotype, and identify the gene and mutation for autosomal dominant cataract (ADC) in an American family of European descent (ADC2) by sequencing the major intrinsic protein gene (MIP), a candidate based on linkage to chromosome 12q13.
This left 121 practices that we believed would be suitable for an analysis based on linkage to problem headings.
Diagnosis at ANC was based on linkage to HIV test results in PMTCT testing registers, or prior VCT.
This population has been genotyped with four nuclear DNA markers selected based on linkage to QTL for resistance to late blight and plant maturity for association analysis [ 55].
However, the assessment of outcome was based on linkage to hospital episode statistics, which may have been associated with less quality assurance than data from a cancer registry.
The strength of this study is the prospective design, the large size, and the complete follow-up based on linkage to national registers (Lunde et al, 1980).
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The third dimension, supplier orientation, is based on linkages to suppliers and includes business process and innovation measures.
By modeling identical-by-descent relationships in multiple related families of canines, Liu et al. [13] derived a random effect model based on linkage analysis to genome-wide scan for the existence of iQTL that affect canine hip dysplasia.
In the first phase of diabetes gene discovery, investigators used techniques based on linkage analysis to identify potential diabetes-associated genes.
PKHD1 is the main gene in ARPKD, but there is compelling evidence for locus heterogeneity why results that are merely based on linkage need to be handled with some care.
We pruned the dataset based on linkage disequilibrium (LD) to reduce the number of tests performed.
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