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In total 13 loci were defined of which six were based on linkage data and seven were based on cytogenetic data.
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19 Evidence regarding adult intelligence quotient (IQ) in relation to Apgar scores comes from studies based on linkage of birth data with results of routine IQ testing at conscription.
This large prospective study is based on linkage between reliable data from two established national registries (Irgens, 2000), and it is unlikely that selection or information bias could have influenced the results.
Developing capacity for comparative monitoring of population-based outcomes based on linkage of routinely collected administrative data has been identified as a priority.
Survival of Irish patients was mainly based on linkage to national mortality data, sometime supplemented with clinical information on date of death.
Our analyses are based on linkage of hospital discharge data to death certificates for all children resident in England, Scotland and Wales who died aged 1 18 completed years.
The symptomatic CRCs were also ascertained based on linkage with national cancer registry data until the end of 2009.
The phase relationship between common alleles can be recovered using population or pedigree data based on linkage disequilibrium or co-segregation, respectively.
These sets were chosen to eliminate any dependency in each test between the two half data sets based on linkage disequilibrium.
A set of markers representing the linkage map at a uniform distance of 0.2 cM was retained from the larger set of GBS SNPs scored, with missing marker data imputed based on linkage intensities and flanking non-missing markers using the Full Sib Family Haplotype Imputation algorithm [ 52].
20 29–31 The work presented here is part of the CHIMES Child Medical Recordss for Safer Medicines) programme in Scotland, a research project which is developing a new system for drug monitoring and surveillance based on linkage of routinely collected paediatric healthcare data from primary and secondary care, and prescriptions dispensed from community pharmacies.
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