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The study was based on linkage between national registers and contains individual-level data gathered consecutively.
Analyses were based on linkage between the Cancer Registry of Norway (CRN) and the Norwegian Arthroplasty Register (NAR).
This large prospective study is based on linkage between reliable data from two established national registries (Irgens, 2000), and it is unlikely that selection or information bias could have influenced the results.
In Denmark, in contrast to the other Nordic countries, the number of maternal deaths reported to WHO is based on linkage between the civil registration system and the national patient register 25.
Others are retrospective case-control studies based on interviews or questionnaires with the risk of recall bias and skewed data due to a high proportion of nonresponders, 19, 22 and some are based on linkage between large administrative registers.
Variables in the database are based on linkage between all inhabitants in Denmark (5.4 million per January 2004), all companies with more than one employee (around 230 000), the taxation authorities, the Registry Relating to Unemployment, the Integrated Student Registry and the Central Population Registry (Statistics Denmark, 1991).
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This explains the small but persistent misclassification error rate of 2% since our imputation is based on linkage disequilibrium between rs592645 and KIR3DL1/3DS1 rather than on perfect discrimination between our target genes.
Selection criteria were based on linkage disequilibrium measurements between the polymorphisms [53].
To improve the precision of gene-level mapping, genome-wide association study (GWAS) based on linkage disequilibrium (LD) between SNPs and causal QTLs/genes is proposed as a more powerful approach identifying genetic links between phenotypes and genotypes [ 14, 15].
In addition, since genomic prediction that uses genome-wide single nucleotide polymorphisms (SNPs) is almost entirely based on linkage disequilibrium (LD) between the SNP alleles and the causative allele(s) at the quantitative trait locus (QTL), combining data with inconsistent phase relationships between the SNP alleles and the causative alleles will serve to destroy evidence of associations.
Herein, based on linkage analysis using F2 progeny between the SUI/ SUI homozygote and the sui/ sui homozygote, we concluded that SUI is controlled by a single dominant locus, which is not linked to the S locus.
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