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Gupta and colleagues highlight recent work, including their own, that suggested based on lineage tracing that mural cells are adipogenic, contrasting with the conclusions of a recent Cell Stem Cell paper.
However, as these experiments were not based on lineage tracing approaches, these conclusions are still debatable.
These conclusions are mostly based on lineage tracing experiments of labelled blastomeres, and their degree of invasiveness is debatable.
A recent study provided compelling evidence based on lineage tracing of cells by tumor mutation analysis that metastasis could occur even before there was a recognizable tumor.
New data proved that such cells do not express other muscle satellite cells markers such as Pax7 or MyoD and based on lineage tracing experiments they are not derived from satellite cell lineage.
In adult MGs, they appear to be maintained by both lineage-specific unipotent stem cells and multipotent basal MaSCs, based on lineage tracing studies (Van Keymeulen et al., 2011; van Amerongen et al., 2012; Rios et al., 2014; Tao et al., 2014; Wang et al., 2014).
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Based on lineage-tracing experiments in mouse embryos, we provide direct evidence that thyroid C cell precursors arise in the endoderm.
Based on a lineage tracing study using PLZF fate-mapping mice, ILC1s and cNK cells originate from distinct progenitors (Constantinides et al., 2015).
Unfortunately, the conclusions drawn by several studies based on genetic lineage tracing of CMs or cardiac progenitor cells differ considerably.
A rough estimate of the contribution of adult-generated neurons to granule cell numbers is 30%, based on a lineage tracing study (Ninkovic et al. 2007).
Based on previous lineage tracing experiments it was concluded that the spongiosa forming osteoblasts originate from invading, periosteum-derived osteoprogenitor cells (Colnot et al., 2004; Maes et al., 2010).
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