For model-based methods, metrics such as the Akaike Information Criterion (Akaike, 1974) and the Bayesian Information Criterion (Schwarz, 1978) are both based on likelihood values and can be used to evaluate how well one model fits the data relative to another model.
We used a likelihood ratio test, based on likelihood values of the Weibull models, to test the null hypothesis that any two FRI distributions were similar [38], [39].
Uninformative positions of the alignment were eliminated using trimal [ 129] and the best-fit protein substitution model was inferred based on likelihood values under AIC criteria, implemented in ProtTest [ 130].
For each type of infection, CRP testing was judged to be evidence-based if at least one valid study reported it to be of significant diagnostic value, based on likelihood ratios, sensitivity, specificity, and predictive values, for the discrimination of viral infections from bacterial infections.
Hazard ratios (HRs) were estimated as the risk associated with an increase equivalent to the magnitude of the interquartile range (25th to 75th percentile) for the adiposity variable of interest (10) with 95% CI using Wald-based standard errors and P values based on likelihood ratio tests.
Tests of statistical significance of the identified clusters were based on likelihood ratio tests, with P-values obtained by 9999 Monte Carlo replications.
c P-value based on likelihood ratio test (LRT).
Age at diagnosis (categorized as 30 49 years vs 50 89 years of age) was found to be an effect modifier of each of the relationships we assessed based on likelihood ratio testing, since P-values for interaction were all <0.05.
Reported p values are based on likelihood ratio tests.
P values were based on likelihood ratio tests and 95percentt confidence limits were calculated by Wald's test [ 23].
