Sentence examples for based on lethal mutagenesis from inspiring English sources

Implications for antiviral designs based on lethal mutagenesis are discussed.

We discuss these results in relation to antiviral designs based on lethal mutagenesis.

Apart from furthering our understanding of the natural history of populations of self-replicating species, this effect raises the possibility of a resistance mechanism to therapies based on "lethal mutagenesis", which would be distinct from and somehow complementary to drug resistance.

Our cluster analysis also indicates that there is strong negative selection against coding changes, which is consistent with our prior work on lethal mutagenesis of RNA viruses [28].

In the course of the studies on lethal mutagenesis of FMDV, biological clones of the virus were subjected to serial cytolytic passages in cell culture in the absence or presence of the mutagenic bases or nucleoside analogues 5-fluorouracil (FU), ribavirin (1-β-D ribofuranosyl-1, 2, 3- triazole- 3 carboxamide) (R), or 5-azacytidine (AZC) [ 32, 38- 41].

Despite the unsolved high fitness in two studies of adapted genomes exposed to a measured level of mutagenesis, the collective quantitative work on lethal mutagenesis suggests a practical approach to extinction.

We excluded data based on synthetic lethal and dosage lethal interactions because they are not necessarily based on physical interactions and have not been systematically determined.

Protein directed evolution based on random mutagenesis and selection offers an alternative strategy to engineer Rubisco.

Recent methodology development in directed evolution of stereoselective enzymes has shown that various mutagenesis strategies based on saturation mutagenesis at sites lining the binding pocket enable the generation of small and smart mutant libraries requiring minimal screening.

However, a possible agonist binding site was proposed based on previous mutagenesis studies.

A similar FST approach was used to develop a rice functional genomics resource based on insertional mutagenesis populations [ 7- 10].