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Special regulatory designations allow drugs to be approved at earlier stages based on less rigorous clinical testing; for example, one review showed drugs with orphan designations or granted accelerated approval are also more likely than drugs without these designations to be tested in single arm studies without placebo or active comparators.
Some of those women have been skipping chemotherapy based on less rigorous research.
Favorable comparisons are made to predictions based on less rigorous describing function or harmonic balance techniques.
Some observers worry that new endpoints could cause FDA's standards to slip: "Is this going to allow drugs to get on the market based on less rigorous studies?" asks Peter Lurie, deputy director of health research at Public Citizen, a Washington, D.C., advocacy group.
25 The results also add to the strength of a recent Cochrane review based on less rigorous studies, 18 which reached similar conclusions.
For example, whereas psychopharmacological interventions have the broadest evidence base, other areas based on less rigorous studies may be similarly relevant for the long-term course of psychiatric disorders.
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Both Kesselheim and Brawley raised some concern about speeding up the FDA's drug approval process, saying that will result in decisions based on less-rigorous science.
However, they are based on less semantically rigorous data structures, rendering them less flexible.
The results of the feasibility studies are verified by rigorous simulations based on less simplifying assumptions.
Lifelong marriages have been based on less.
Mr. Neff said his early optimism about Palm was based on a less rigorous methodology than he applied to the stock later.
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based on less prevalent
based on less concrete
based on less compelling
based on less detailed
based on less complete
based on less systematic
based on less solid
based on less toxic
based on less realistic
based on less abstract
based on less tangible
based on less similar
based on less analytical
based on less definitive
based on less experimental
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Justyna Jupowicz-Kozak
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