Tumours were evaluated on lesion morphology, margins, internal enhancement, kinetics and BI-RADS classification.
A BI-RADS classification was assigned for each lesion based on their morphology and enhancement dynamics [ 28].
Further sub-classification within each of these three groups is predominantly based on inclusion morphology and lesion distribution [ 15, 84, 85], although other characteristics may also be utilized, such as, tau isoform dominance, phosphorylation and ubiquitination status, and cleavage sites.
The histological staging was based on histological lesion, including glomerular lesion [ 16], tubulointerstitial lesion, focal glomerulosclerosis [ 17], and fibrointimal lesion.
MIN lesions were identified based on their morphology on MR images.
Although pathologists often use E-cadherin staining to distinguish between these two lesions, IHC has many well-described pitfalls [ 30- 35] and many pathologists prefer to differentiate these lesions based on morphology alone.
The expert radiologist differentiated risk estimates for lesions based on morphology such as classifying round, coarse, vascular, or punctate microcalcifications as low-risk as opposed to pleomorphic or fine linear/branching microcalcifications which were classified as higher risk.
Based on the morphology and enhancement pattern of lesions, contrast-enhanced MRI offers an overall sensitivity of 90% and specificity of 72% in detecting breast lesions according to a published meta-analysis [ 2].
In MS IFNβ production was detected in active lesions in cells defined as macrophages and astrocytes based on their morphology [ 41].
