Therefore, while this study has established the feasibility of annotating potential tumor sources of cfDNA using FCH PET/CT imaging, the clinical translational value of these distinctly different measures of tumor activity as potential diagnostic markers of tumor response will need to be based on larger studies in the future.
Thus, there is insufficient data in the literature on the anatomy of the cervical spine, especially based on large study populations.
Most of our knowledge of norovirus infection and epidemiology is based on large studies in the United States and in European countries, which may skew our understanding of norovirus characteristics toward the kinetics observed specifically in white populations.
Third, the data for Russia-specific RRs are based on one large study and, as a consequence, some RRs were not significant [ 14] and, thus, were not used.
Future studies based on larger cohort studies should determine the different weights of potential predictive factors of QoL.
Future studies based on larger cohort studies should provide supplementary findings to validate these preliminary results and determine the different weights of potential predictive factors of QoL, allowing the adaptation of appropriate care strategies for children and their caregivers.
There is a considerable need for development of country or region-specific data based on larger longitudinal studies.
As this scattering is due to tumour heterogeneity, neither studies based on larger series nor studies conducted over longer periods would be able to eliminate this obstacle.
The so-called evidence-based medicine and the adoption of treatment standards based on large epidemiological studies or randomized controlled trials have significantly hampered the efforts to truly personalize the medical practice.
