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Recommendations with an "A" rating are based on large well-designed clinical trials or well-done meta-analyses.
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More studies based on larger population and well-designed, especially studies investigating the combined effect of Gly460Trp and other polymorphisms are required to further evaluate the role of these polymorphisms in hypertension.
Based on results from a number of large, well-designed clinical trials it is generally accepted that interferon beta (1b or 1a) is the treatment of choice for patients with RRMS (Polman & Uitdehaag 2000; Stuart 2004; Stuart et al. 2004).
The method has been applied on a scaled-down semiconductor manufacturing system, and the quality of the quoted lead time has been evaluated based on a large and well-designed validation data set in terms of the six commonly used performance criteria.
Large, well-designed RCTs and the meta-analyses based on these trials remain the gold standard.
IPA utilizes a large, well-designed knowledge base and enables functional, canonical pathway and network analysis.
26 The results of our method were compatible with those of large well-designed studies in other contexts, in which participants from the population were offered check-ups, based on specified criteria.
Such trials are unlikely to have any clinical impact and should be abandoned in favor of large, well-designed trials with endpoints that will impact on clinical practice.
The bunkhouse is simple and comfortable with large well-designed bathrooms and showers.
Large well-designed trials are needed to compare the efficacies of vitamin K1 and K2 on fractures.
Future large, well-designed studies are warranted to examine the impact of PTPN22 and CTLA-4 on LADA risk.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com