Thus, increased attention must be paid to China's warm-temperate zone and to the influences of Quaternary climate change in this area based on large-scale genetic studies with extensive sampling.
Estimates of the risks associated with these genetic variants based on large population-based association studies are likely to be applicable also to mutation carriers after taking ER status into account.
Gene-gene and gene-environment interaction analyses based on large populations increase the power to detect novel variants and more accurately characterize the genetic effects.
Herein we report a high-density genetic map for soybean, which is constructed based on large-scale markers developed by specific length amplified fragment sequencing (SLAF-seq).
Genetic heterogeneity of effective pollen pools was reported in other studies based on larger sample sizes [ 15, 37].
Rosenberg et al. (2002) published the first description of human genetic diversity based on a large number of genetic markers and concluded in contrast with the data presented in this lab that genetic diversity in humans clusters by continent.
Based on the genetic analyses, the large number of singletons in MT4 cultures point to strong selection whereas the higher polymorphism level in the 'non-adapted' C8166 replicates might be indicative for 'clonal interference' between clones with marginal fitness effects competing to achieve fixation [38] [44].
Based on a large-scale genetic interaction map of the secretory pathway, we previously suggested that three otherwise unassociated yeast proteins (Mdm39/Get1, Rmd7/Get2, and Arr4/Get3, the yeast homolog of Asna1/TRC40) cooperate to carry out a common function that strongly impacts on trafficking and, accordingly, named them Get1 3 (Golgi ER trafficking 1 3) (Schuldiner et al., 2005).
At one end of the spectrum, a Leptospira species may be clearly genetically distinct from other members of the genus based on a large degree of genetic diversity.
Unlike common variants, rare variant analyses, based on single genetic associations, often shows large false-negative results, unless the sample or effect sizes are very large.
