Sentence examples for based on known structures from inspiring English sources

These do not require strict adherence to known 3D structures, they do allow variation, but still based on known structures.

However, it is difficult to predict interaction between the protease and substrate based on known structures [28], [29], as once initial cleavages of hemoglobin take place, the structure of hemoglobin will be altered, and multiple peptide bonds will presumably be accessible to cleavage by the falcipains.

Essentially, it is a statistical analysis based on known structures in PDB.

When a protein-protein interaction involves an intrinsically disordered partner, the methods developed for predicting protein-protein interactions based on known structures are simply not applicable.

So far only structures of the calcium-bound state have been solved (Fig. 1) [16], but it was possible to propose a model for the calcium-free state based on known structures of calcium-free EF-hand pairs (Fig. 5).

Therefore, the 3D structures of TRR1 and KRE2 of P. brasiliensis were constructed by homology modeling based on known structures with high percentage of identity in amino acid sequences.

Structural classification of proteins (SCOP), is a database that classifies all proteins based on known structure, function and sequence (Murzin et al., 2005).

Quintyn et al. have shown, for example, that for three D2 homotetramers, transthyretin, streptavidin and neutravidin, a dimer dimer interface is cleaved, as would be expected based on known structure.

Since the sequence alignment of porcine and A. thaliana β-tubulin isotypes revealed approximately 85% sequence identity, it is reasonable to assume that homology modeling based on known structure of bovine brain tubulin [ 6] combined with the high resolution model of microtubules [ 8, 9] produces a model of A. thaliana microtubule protofilaments acceptable with a high degree of confidence.

Phasing short read data typically requires supplemental statistical phasing based on known haplotype structure in the population or parental genotypic data.

To study the distribution of identified loci according to gene functional units, the genome was divided into promoter, exon, intron and inter-gene regions based on known gene structure.