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Then based on known haplotypes, it predicts untyped genotypes.
We performed simulation studies based on known haplotypes and real microarray noise, demonstrating that this tool successfully inferred haplotypes and diplotypes from noisy microarray data, and that the tool even had an ability to correct total copy numbers and unphased genotypes that are wrongly determined due to noise.
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Phasing short read data typically requires supplemental statistical phasing based on known haplotype structure in the population or parental genotypic data.
We selected potential functionally relevant SNPs including non-synonymous coding SNPs, and 1 15 haplotype tagging SNPs were genotyped based on known patterns of LD using data available from the HapMap CEU population.
The resulting haplotypes of the 10 tested sires by the daughter design were verified by LSPH software that is based on known genetic relationships between individuals (Baruch et al. 2006).
It is based on known information.
Antibodies were selected based on known performance.
Testing of the initial amplicon designs on a diversity panel of DNAs showed that in most cases results were consistent with expectations based on the known haplotype sequences.
Based on the other known haplotypes in the dataset, we had counts n Ai, n Bi of the number of A alleles and B alleles, respectively, with haplotype i.
Beagle performs a local clustering of haplotypes at each marker position to define the hidden states whereas MaCH samples pairs of known haplotypes for each individual based on the observed genotypes in each round of the HMM.
First, it gathers haplotype clusters at each marker and defines an HMM to find the most likely haplotype pairs based on the known genotypes of each individual.
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