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This paper proposes a new approach based on knowledge structures for building simulation models.
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The FOL library was created based on knowledge of protein structures and their cognate metabolite-binding partners for structure-based drug discovery, and was previously used to identify modulators of leukotriene A4 hydrolase [18].
For spatial analysis, spatial systematic sampling or stratified random samplings based on knowledge of spatial structure are sometimes more appropriate.
Rational strategies for identifying novel drug therapies are typically based on knowledge of the structure of the target proteins and the design of new chemical entities that modulate these proteins in a beneficial manner.
Based on knowledge of the structure of known environmental THDCs, halogenated aryl compounds, with a hydroxy group at a position similar to the natural ligand thyroxine (T4), are traditionally suspected to have TTR-binding potencies.
We have developed a novel technique [ 11] which designs aptamer candidates directly based on knowledge of the target structures.
For greater accuracy more rigorous modelling approaches based on knowledge of the foods structure would be required.
To that end, Nakamoto and co-workers [66] stated that, site group or factor analysis, based on knowledge of the crystal structure, is desirable when taking into consideration the symmetry of the ligand, from the spectra obtained, in the crystalline state.
Selection of the CEL6A sites for engineering was based on knowledge of the enzyme structure and guided by sequence alignments.
The fabrication of hydrogel-based cellular scaffolds for the generation of bioengineered tissues has been based on knowledge of the composition and structure of ECM.
To optimise the sensitivity of the biosensor for such compounds we have chosen a rational design of the inducer-binding cavity based on knowledge of the three-dimensional structure of DntR.
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