This conclusion is based on kinetic studies of HIV-1 replication during the primary antigen specific CD4+ T cells in vitro where R5 virus growth was selectively dampened by the synthesis of anti-viral CCR5 ligands by the responding T cells.
Based on kinetic studies, this increased fecal loss appears to be secondary to an interrupted enterohepatic circulation of bile acids [ 20, 21].
Goh et al. tested plated femora using 20%, 40%, and 60% of body weight to simulate progressively increased weight bearing in the early postoperative period, using values based on kinetic studies in dogs [ 20, 21].
Pol δ was shown to have high selectivity for the correct nucleotide based on kinetic studies of the insertion of individual dNTPs opposite a known nucleotide in a DNA template.
Based on kinetic studies, argininosuccinate synthesis was initially postulated as a key urea cycle control node [ 41], although normal urea cycle operation is assumed to rely more on other parameters such as pH, ammonium availability, and N-acetyl-glutamate levels [ 42].
Based on kinetic studies and the effects of PKC inhibition on the aggregation response to vasopressin, significant heterogeneity in the aggregation response of normal human platelets to vasopressin has been demonstrated, which is probably related to a polymorphism of the platelet V1R [ 49].
These results questioned the results of Schrimsher and Taylor who proposed, based on kinetic and inhibitor studies, that NADH binds first followed by a random binding of L-arginine and pyruvate [12].
The large amplification of ee observed in this autocatalytic reaction is often explained by the formation of aggregates, which has been proposed to account for the positive nonlinear effect observed during asymmetric catalysis.[ 11] Mechanistic studies based on kinetic experiments,[ 12] reaction modeling,[ 13] NMR,[ 14] and DFT calculations[ 15] have been examined by several research groups.
