Sentence examples for based on its potency from inspiring English sources

Based on its potency, HCI-2389 was selected to treat the Nek2-OE HeLa cells.

5,6-Dimethylxanthenone-4-acetic acid, with a methyl substituent on both the 5- and 6-position, was selected as a clinical candidate from all the xanthenone and flavone derivatives synthesised at the Auckland Cancer Society Research Centre, based on its potency and activity against solid murine cancers that are resistant to conventional chemotherapies (Rewcastle et al, 1991).

There have been several ways reported to calculate such a bias of a ligand based on its potencies and efficacies in G protein activation and β-arrestin recruitment assays.

The macrocycle was not as effective in whole cell binding assays as would be expected based on its extracellular binding potency.

Based on its in vitro potency, the spectrum of in vivo and clinical activity against human tumours, and its tolerability in human patients, SG2000 has potential as a novel therapeutic against spontaneously occurring canine malignancies.

The choice of dexamethasone was based on its high anti-inflammatory potency, negligible mineralocorticoid effects at therapeutic doses, and long duration of action [ 30].

Based on its exceptional kinase selectivity, great potency and metabolic stability, 15l represents a promising lead for the discovery of RET directed therapeutic agent and should be a key tool in studies aimed at understanding RET biology.

Based on its toxicity profile and experimental potency, dexverapamil, the R-enantiomer of verapamil, is considered to be promising for clinical use as a chemosensitizer.

In particular, 3,5-bis(4-chlorobenzylidene)-1-[3-(2-hydroxyethylsulfanyl]propanoyl-4-piperidone 4-chlorobenzylidene -1-[3- 2-hydroxyethylsulfanyl]propanoyl-4-piperidoneevertant properties, cytotoxic potencies and tumour-selective toxicity.

The crystal structure of NAMPT in complex with APO866 has previously led to suggestions on improving the potency of APO866 based on its interaction with the NAMPT binding site [ 14, 43].

Its use in the current vaccination program was permitted through shelf life extension based on satisfactory potency testing.