Sentence examples for based on interim information from inspiring English sources

Flexible designs for clinical trials permit mid-trial design modifications, which are based on interim information from inside or outside the trial while meeting (regulatory) requirements for the control of the type I error rate.

Two trials reported changes to the primary endpoint based on interim analysis [ 9, 15], one introduced an additional (secondary) endpoint [ 22] and one dropped an endpoint [ 23] subsequent to interim analyses.

No treatment change was made based on interim PET scan results.

An interview guide was used and was adjusted during the process of interviewing based on interim reviewing of the results.

One potential early prognostic marker that this study investigated is metabolic response based on interim and posttreatment FDG-PET.

Recommendations made by the DMC or based on interim analysis were identified and potential sources of bias assessed.

This is in contrast to adaptive designs that can alter the sample size based on interim results.

A tailored therapy based on interim PET is under study in many ongoing trials but at the present time it is not recommendend to change therapy on the basis of the results of an interim FDG-PET.

Following each interim analysis, the Data Monitoring Committee made recommendations to continue, modify, or stop the trial, based on interim analysis results (stopping criteria at n1 = 60, boundary P-value = 0.00015; n2 = 40, boundary P-value = 0.00258; n3 = 100, boundary P-value = 0.02396).

Furthermore, when therapeutic responsiveness of patients is assessed based on interim growth or shrinkage of a tumour rather than the definitive clinical outcome, unsupervised clustering may be used to validate this supervision information, either to support it or to raise uncertainty about this 'ground-truth' if the correlation between the cluster labels and assessed responsiveness is weak.

However, it is still not proven that modifying therapy based on interim-PET can improve patient outcomes.