Sentence examples for based on interim data from inspiring English sources
In particular, equipoise provides flawed ethical guidance for placebo-controlled trials and for decisions to terminate trials early based on interim data relating to benefit.
Because the DMC recommended early discontinuation of the study drug based on interim data, thereby decreasing the study's statistical power, additional study conclusions are limited.
In February 2011, based on interim data as of October 2010 from 219 patients, the DMC recommended that all patients discontinue study treatment.
According to this principle there must be a state of equipoise regarding the benefit-to-risk ratio of the interventions under investigation in order to justify randomization, and trials must be stopped when this equipoise has been disturbed based on interim data [ 20].
48 In a phase III study of docetaxel versus best supportive care in patients with non-small cell lung cancer previously treated with platinum-based chemotherapy, the docetaxel dose was reduced from 100to7575 mg/m based on interim safety-data monitoring which identified a significantly higher toxic death rate in the chemotherapy arm of the study.
However, according to Novo Nordisk, it seems that the US Food and Drug Administration has accepted a resubmitted marketing authorization application based on interim analysis of data from the DEVOTE study.
An interview guide was used and was adjusted during the process of interviewing based on interim reviewing of the results.
One potential early prognostic marker that this study investigated is metabolic response based on interim and posttreatment FDG-PET.
Recommendations made by the DMC or based on interim analysis were identified and potential sources of bias assessed.
This is in contrast to adaptive designs that can alter the sample size based on interim results.
