Sentence examples for based on interim and from inspiring English sources

One potential early prognostic marker that this study investigated is metabolic response based on interim and posttreatment FDG-PET.

[ 1] It is unclear to what extent protocol modifications have been made in trials based on interim analyses, and more specifically as a result of recommendations by DMCs.

Based on interim kills and gross pathologic observations, the main conclusions are: increased cytoplasmic vacuolation of hepatocytes was seen in the livers of rats given 200 ppm VDC in drinking water or 25 or 75 ppm VDC vapor by inhalation; based on gross tumor count, tumor incidence in VDC-exposed rats was not greater than controls.

The clinical results of risk stratification based on interim PET and the fact that FDG uptake reflects the metabolic activity of the surrounding inflammatory cells rather than the HRS cells again highlights the importance of the tumor microenvironment in the pathogenesis of HL.

Recommendations made by the DMC or based on interim analysis were identified and potential sources of bias assessed.

An adaptive trial design would permit enrichment of the responder population as well as more efficient randomization of patients to dose groups based on interim assessments of efficacy and futility status against a priori boundaries.

Two trials reported changes to the primary endpoint based on interim analysis [ 9, 15], one introduced an additional (secondary) endpoint [ 22] and one dropped an endpoint [ 23] subsequent to interim analyses.

Experienced entrepreneurs understand investor expectations of Board representation, preferred stock, and payments based on interim milestones.

Based on interim results the independent Safety Monitoring and Advisory Board may decide to use the same adjudication procedure for other outcomes of interest too.

In the majority of cases, recommendations were made based on interim analysis in the interest of participant safety and it is reassuring that there was only a small proportion of trials where extended use of interim analysis or recommendations made by the DMC had the potential to introduce bias.

In particular, equipoise provides flawed ethical guidance for placebo-controlled trials and for decisions to terminate trials early based on interim data relating to benefit.