Sentence examples for based on interim from inspiring English sources

Two trials reported changes to the primary endpoint based on interim analysis [ 9, 15], one introduced an additional (secondary) endpoint [ 22] and one dropped an endpoint [ 23] subsequent to interim analyses.

48 In a phase III study of docetaxel versus best supportive care in patients with non-small cell lung cancer previously treated with platinum-based chemotherapy, the docetaxel dose was reduced from 100to7575 mg/m based on interim safety-data monitoring which identified a significantly higher toxic death rate in the chemotherapy arm of the study.

Moreover, our design can be extended to allow patient level covariates via logistic regression, now adjusting sample size within each subgroup based on interim analyses.

In particular, equipoise provides flawed ethical guidance for placebo-controlled trials and for decisions to terminate trials early based on interim data relating to benefit.

Flexible designs for clinical trials permit mid-trial design modifications, which are based on interim information from inside or outside the trial while meeting (regulatory) requirements for the control of the type I error rate.

We recently proposed a 2-stage phase II design that has the option for direct assignment (i.e., stop randomization and assign all patients to the experimental arm in stage 2) based on interim analysis (IA) results.

However, it is still not proven that modifying therapy based on interim-PET can improve patient outcomes.

It should be noted that if there appears to be an unexpectedly high number of repair breakdowns among short-term catheterization cases compared to long-term catheterization cases either as reported by study site staff or the study monitor, or based on the interim analysis, any one of the study Institutional Review Boards (IRBs) may also temporarily or permanently halt the study at any time.

Wyeth and its partner in the project, the Elan Corporation, announced last year that they had moved to a Phase 3 study of the product based on an interim look at the results announced on Tuesday.

The last seven years of negotiations were based on an interim peace agreement, the Oslo agreement, that was supposed to prepare the two sides gradually for the concessions required by a permanent peace accord.

"This is about what was expected based on the interim analysis," he says.