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Similarly, all significantly deregulated miRNA genes were also prioritized based on integrative pathway analysis of their target genes retrieved from experimentally supported databases.
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Here we present evidence of an ROS-mediated regulatory module that functions as an early component of the chilling stress response pathway in japonica rice based on integrative genomics analysis.
In this study, we aimed to investigate potential therapeutic compounds for lung adenocarcinoma based on integrative analysis.
These genes were selected based on integrative evidence from linkage, association, gene expression and literature search.
MiRNA-mRNA networks were designed based on integrative analysis of the microarray data.
Despite over 60,000 reports on MI [ 2, 3], there is still a pressing need to better define the disease biology of this condition based on integrative, systematic approaches.
Based on this integrative pathway analysis, we defined these 13 pathways as candidate pathways for prostate cancer.
Finally, functional pathways were annotated based on KEGG pathway analyses.
The list of significant genes was used for pathway enrichment analysis based on KEGG human pathway database.
Functional association analysis performed by ToppCluster based on pathway networks showing enriched terms from Gene Ontology and pathways.
More recently, an integrative approach based on disease-specific pathways has revealed that PDGFRL may play a critical role in promoting breast tumorigenesis [ 80].
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