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We were unable to culture enough NCS proband (p.Phe296Leufs*26) fibroblasts to reliably detect a WDR73 band by immunoblotting, but would predict reduced abundance of both WDR73 p.Phe296Leufs*26 and p.Arg256Profs*18 based on instability of the recombinant versions of these proteins (Fig. 6F and G).
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The progression of paraspinal muscle recruitment intensity in localized and global strength training exercises is not based on instability alone.
In this update, taking into account new data from the literature, we propose to use the same allele range definition for normal allele as the one used in several other guidelines and based on the instability of the allele, that is, normal allele up to 44 CGGs and intermediate alleles from 45 to 54 CGGs.
A novel criterion for the transition from mono-plate to multi-plate based on the instability of the wavy-edge plane is proposed.
The strategy was based on the instability of the N-SH bond.
It is based on the instability of R5 at endosomal low pH and low Ca2+.
Based on the instability of this mutant (see below), and its secondary structure content which resembles that of the wt apoenzyme [ 39] (see also below), this band may represent a cofactor-free apoform of mutant HMBS [ 38].
iii) The instability index provides an estimate of a protein's folding stability in vitro, based on estimated instabilities of the protein's dipeptides.
An attempt was also made to develop a criterion for predicting the onset of slugging based on the instability analysis of stratified flow in minichannels.
Robustness of the inference approximation is important for experimental design, since decisions should not be based on numerical instability artefacts of the method, but on the data alone.
A rationalization of these results is offered based on an instability triggered by the interaction of elastic stick slip waves with pre-existing twin boundaries.
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