The model is implemented as a simulation software that can be used to predict gene transcription levels based on a set of parameters, as well as estimate some parameters based on information about gene transcription levels or their changes under knock-out or heat-shock conditions.
The Gompertz function was selected to describe kernel growth based on information criteria, biological interpretation of the parameters, and computational ease.
The design parameters were based on information available from the 1-year results of the ATAC (Arimidex, Tamoxifen Alone or in Combination) study.
We have also made model parameter choices based on information available in the literature from past pandemic outbreaks.
For purposes of illustration, we shall use nominal parameter values based on information for the wild-type lac operon of Escherichia coli.
The model, developed in the framing of other similar methods proposed in the past, needs a limited number of parameters and is based on information collected in the aftermath of the 2009 L'Aquila earthquake.
The framework is based on information-theoretic measures, heuristic search strategies, parameter estimation criteria, a mixture of forward-backward phases, and a gene aggregation scheme.
Markers were then called as N. vitripennis (V), N. giraulti (G), or ambiguous (U) based on three parameters (supporting information, File S1).
They are based on market information, and cost parameters as well as functional relationships can be updated at any time.
They built a prognostic model based on mutational information with clinical parameters, which was superior to a standard model simply based on the International Prognostic Scoring System, and provided a tool for improved diagnosis, biological subtyping, and prognostication for patients.
