Although the actual curves and the quantitative results would be different for each specific study, the methodology of selecting a sample based on individual and network characteristics will guide future studies.
Classifier discovery based on individual TF networks could yield more mechanistically-oriented biomarkers.
Unlike conventional expression diagnostic markers based on individual genes, these network-based diagnostic markers should be inherently more reliable since they provide the biological interpretation for the association between the subnetwork biomarker and the particular type of disease [ 32].
But to avoid the appearance of one TV network's fare getting more attention, marketers looking to advertise there will not be able to buy advertising based on individual shows or networks, but rather according to genre or demographic data.
The first of these, NetRank [ 11], is based on individual genes with the network information incorporated in the feature selection procedure.
A functional interaction network based on individual genes was constructed using the Reactome FI network Cytoscape plugin application (http://www.reactome.org/), which utilizes a database (2013 version) of protein-protein interactions, gene co-expression, protein domain interactions, GO annotations, and text-mined protein interactions [ 16].
Other management practices, based on individual negotiations, presumably depended on internal provider networks, whose development, and also decline, could not be captured through our study methods.
In the absence of formal, sustained support to research network development, informal research networks among individuals develop ad hoc, based on individual champions.
The aim is that national infrastructures will be linked together in one giant network, using a 'hubs and spokes' model based on individual countries.
