Sentence examples for based on individual SNPs from inspiring English sources
In finding susceptibility loci for complex diseases, haplotype-based methods are more powerful and robust than the methods based on individual SNPs (Akey et al., 2001).
It is not accurate to determine the genotype of the F2 population based on individual SNPs.
It has been proposed that an analysis based on haplotype analysis is more powerful than that based on individual SNPs in the presence of multiple susceptibility alleles [19].
Bin maps were constructed for the 210 RILs based on individual SNPs and adjacent bins with the same genotype were lumped (see Materials and Methods for details), resulting in a map consisting of 1,619 recombinant bins without missing data (Table S2, Figure 1).
For genetic assignment based on individual SNPs, there are six accessions from Central Asia assigned to the Western population (data not shown).
Another important aspect of our analysis is that it highlights the significance of the overall allelic architecture of Cox-2 on disease risk rather than its effect based on individual SNPs in isolation.
Prior to analysis, we subjected SNPs to multiple levels of quality control based on individual SNP call rates across the larger population data set of 210 individuals (including both the LCL and PBMC genotypes from the 16 individuals described here).
Prior to SNP association analysis, unstandardized EBV were deregressed and corresponding weights were calculated based on individual and parental EBV and reliabilities [ 9].
Based on these individual SNPs, bin maps were constructed for all 210 RILs, and the co-segregating markers in two contiguous block borders were lumped as a bin, resulting in a skeleton bin map consisting of 2,386 recombinant bins distributed throughout the genome (Fig. 2).
We performed association tests on individual SNPs and haplotypes of SNP combinations.
