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All these observations based on imputed values have been removed in our sample.
Additionally, any analysis based on imputed values (rather than direct estimation of a parameter of interest) would benefit from a multiple imputation procedure.
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We computed likelihood ratio tests comparing the significance of nested models using models based on one imputed value.
26 The main reasons for the unexpected finding of a null association between cholesterol level and cardiovascular risk were omission of the cardiovascular disease outcome when imputing missing cholesterol values and calculation of the ratio of cholesterol to HDL based on imputed cholesterol and HDL values, which led to extreme values of the ratio being included in estimations.
The results are similar though the absolute values tend to be marginally lower than the analyses based on imputed data.
Here, the comparison was exclusively based on imputed markers in data for the lines from the test population in order to focus solely on the accuracy of imputed marker values.
Results presented here are based on imputed data.
We therefore display results based on imputed data.
We only present results based on imputed datasets.
‡Treatment effects are ratios of means based on imputed data.
Estimates are based upon imputed values when data are missing (see eTable 4 on missing data).
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com