Biologic targeted therapy is based on molecules implicated in molecular pathways relevant to the biology of the breast cancer cell.
17 For miRNA expression analysis, we selected a specific panel of miRNAs based on reports implicating them in OPC development.
Based on observations implicating class B scavenger receptors in the uptake of Mycobacterium fortuitum[ 35], we hypothesized that disruption of the Cd36 gene would result in an altered host response to mycobacterial infection.
However, dust from the Gobi desert might not be the only source of ambient influenza virus, based on evidence implicating the contribution of African dust to bacterial and fungal CFU concentrations in ambient air in the Caribbean and the Mediterranean (Polymenakou et al. 2008; Prospero et al. 2005).
An inhibitor screen was performed using a variety of broad spectrum or specific inhibitors (Table 1) based on signalling pathways implicated in EPEC subversive events.
Recent studies based on cfos detection implicated the Dm subdivision of the zebrafish telencephalon in the innate anxiety-like response displayed in a dark-light box (Lau et al., 2011), and we confirm these results in the present work.
Based on prime implicates canonical representation, we first introduce the notion of conflicting variable and use it to refine an existing inconsistency measure defined by minimally unsatisfiable sets (MUSes).
Based on prior research implicating heightened negative affect and amygdala hyperactivity in NSSI, we pursued a systems approach to characterize amygdala functional connectivity networks during rest (resting-state functional connectivity [RSFC ]) and a task (task functional connectivity [TFC]) in adolescents with NSSI.
For this reason, and based on previous studies implicating the rIFG in similar face-processing tasks [13], [43] [45], we conducted a subsequent between-group analysis focusing specifically on the right prefrontal cluster, using a functionally defined region-of-interest (ROI) derived from the group mean of the TD children in the Task-Rest contrast.
Our model for the involvement of the DA pathway in determining some of the core deficits of ASDs is based on earlier results implicating the DBH gene as a maternal effect locus, and on our hypothesis that autism susceptibility is determined by a combination of fetal susceptibility genes and fetal gender as well as maternal effects including maternal genetic factors [ 18].
