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Pathways selected that are statistically significant based on hypergeometric statistics.
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Enrichment statistics were computed based on hypergeometric distribution and adjusted with Benjamini-Yekutieli's multiple testing correction [ 70] which takes into account the dependency among GO terms.
For cellular pathway analysis, MetaCore is based on hypergeometric distribution, SAM-GSA uses "Maxmean" statistic, and GSEA uses modified Kolmogorov-Smirnov statistic.
Acupuncture meridians and points were found to overlie the fascial planes between muscles, and this association was determined to be statistically significant based on hypergeometric analyses [7].
Calculation of statistical significance throughout MetaCore was based on P value, calculated based on hypergeometric distribution [ 14].
All the enrichment analyses are based on hypergeometric tests with the Benjamini Hochberg approach [28] for multiple testing correction.
We calculated the probability values based on hypergeometric distribution instead of chi-square distribution, which is used in the original ACME.
Based on hypergeometric distribution, we carried out a function enrichment analysis between the progression-related sub-network and the whole human biological network.
P values were calculated based on hypergeometric distribution analysis.
Methods based on hypergeometric distribution, if properly implemented, are also fast.
The p-value was calculated based on hypergeometric cumulative distribution function.
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